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Prescription drug abuse is the intentional non-therapeutic use of a prescription drug, even after, for its worthwhile psychological or physiological outcomes.
A person caring for you need to find emergency professional medical notice In case you have gradual respiration with prolonged pauses, blue colored lips, or if you are hard to awaken.
The concomitant usage of anticholinergic prescription drugs with Promethazine with Codeine Oral Remedy may perhaps improve risk of urinary retention and/or significant constipation, which can produce paralytic ileus [see Warnings and Safeguards ( five.eleven) ]. Monitor individuals for indications of urinary retention or decreased gastric motility when Promethazine with Codeine Oral Resolution is applied concomitantly with anticholinergic drugs.
Sedating medication may well cause confusion and in excess of-sedation inside the aged; aged people typically needs to be started off on low doses of promethazine with codeine syrup and observed closely.
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Postmarketing instances of respiratory despair, like fatalities, have already been claimed with utilization of read more promethazine hydrochloride in pediatric patients below 2 several years of age. A wide array of excess weight-dependent doses of promethazine hydrochloride have resulted in respiratory depression in these sufferers.
Use: With the administration of mild to moderate discomfort the place remedy by having an opioid is acceptable and from which choice solutions are insufficient.
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Promethazine is metabolized from the liver to a variety of compounds; the sulfoxides of promethazine and N-demethylpromethazine will be the predominant metabolites showing up from the urine.
Use warning When contemplating using Promethazine with Codeine Oral Resolution in individuals sixty five several years of age or older. Aged clients might have amplified sensitivity to codeine; larger frequency of reduced hepatic, renal, or cardiac functionality; or concomitant here ailment or other drug therapy [see Warnings and Precautions ( five.six) ]. Respiratory despair may be the Main threat for aged individuals addressed with opioids, like Promethazine with Codeine Oral Solution. Respiratory melancholy has happened right after significant Preliminary doses of opioids were being administered to individuals who weren't here opioid-tolerant or when opioids were being co-administered with other agents that depress respiration [see Warnings and Safeguards ( five.
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